The Catalans lead their fierce rivals by three points and are also better off in the head-to-head, meaning they will triumph should the two sides finish with the same points total at the end of the campaign.
Real Mallorca's hopes of earning a top-four finish suffered a potentially crucial setback after they became the first team to lose to Deportivo La Coruna in over two months. Mallorca are a point behind going into their final game at home to Espanyol, while Sevilla make the short trip to mid-table Almeria.
Leaders Barcelona will have a tricky away game on Saturday as they will meet in-form La Coruna away from home. Barcelona are two points clear of Real Madrid but they will have to keep up the pace if they want to remain in the lead. Deportivo are currently 12th in the league but they are in good shape and grabbed a surprising 2-1 win at Bilbao last weekend.
Real Madrid will travel to meet 13th placed Deportivo La Coruna on Saturday and Mourinho's men will have to win if they want to keep the pressure on leaders Barcelona. Last week Real Madrid eased past lowly Levante while Deportivo grabbed a 1-1 draw at Almeria.
